Publications
 

Bold and underlined author names indicate members and trainees of the Eskiw Lab

LR Zehfus, ZE Gillespie, C Almendáriz-Palacios, NH Low, CH Eskiw Haskap Berry Phenolic Subclasses Differentially Impact Cellular Stress Sensing in Primary and Immortalized Dermal Fibroblasts. Cells 10 (10), 2643

IS Mehta, K Riyahi, RT Pereira, KJMeaburn, M Figgitt, IR Kill, CH Eskiw, JM Bridger, Interphase Chromosomes in Replicative Senescence: Chromosome Positioning as a Senescence Biomarker and the Lack of Nuclear Motor-Driven Chromosome Repositioning in Senescent Cells, Frontiers in Cell and Developmental biology 9, 593

Almendáriz-Palacios C, Gillespie ZE, Janzen M, Martinez V, Bridger JM, Harkness TAA, Mousseau DD, Eskiw CH. The Nuclear Lamina: Protein Accumulation and Disease. Biomedicines. 2020 Jul 1;8(7):E188. doi: 10.3390/biomedicines8070188.         

                     

LR Zehfus, CH Eskiw, NH Low Phenolic profiles and antioxidant activities of Saskatchewan (Canada) bred haskap (Lonicera caerulea) berries,  BioRVX

TG Arnason, V MacDonald-Dickinson, JF Davies, L Lobanova, C Gaunt, B Trost, M Waldner, P Froese, D Borrowman, H Marwood, ZE Gillespie, FS Vizeacoumar, FJ Vizeacoumar, CH Eskiw, A Kusalik, TAA Harkness Anaphase Promoting Complex activity mediates clinical responsiveness to recurrent canine lymphoma bioRxiv

C Almendáriz-Palacios, DD Mousseau, CH Eskiw, ZE Gillespie. Still Living Better through Chemistry: An Update on Caloric Restriction and Caloric Restriction Mimetics as Tools to Promote Health and Lifespan. International Journal of Molecular Sciences 21 (23), 9220

   

Almendáriz-Palacios C, Gillespie ZE, Janzen M, Martinez V, Bridger JM, Harkness TAA, Mousseau DD, Eskiw CH. The Nuclear Lamina: Protein Accumulation and Disease. Biomedicines. 2020 Jul 1;8(7):E188. doi: 10.3390/biomedicines8070188.        

                     

Belak Z., Pickering, J.A., Gillespie Z.E., Audette G.F., Eramian M., Mitchell J.A., Bridger J.M., Kusalik A. and Eskiw C.H.  Genes responsive to rapamycin and serum deprivation are clustered on chromosomes and undergo re-organization within local chromatin environments.Biochemistry and Cell Biology, 98(2):178-190 
 

Clements, C.S., Bikkul, M.U., Ofosu, W., Eskiw, C.H., Tree, D., Makarov, E., Kill, I.R., Bridger, J.M. (2019) Presence and distribution of progerin in HGPS cells is ameliorated by drugs that impact on the mevalonate and mTOR pathways. Biogerontology: 1-22. DOI: 10.1007/s10522-019-09807-4
 

Xiang, W., Belak, Z., Eskiw, C., Ghosh, S., Shand, P.J. (2019) Biochemical and Gelation Properties of Mechanically Separated Pork. Meat and Muscle Biology: 2(2): 177-177. DOI: 10.221751/rmc2018.155
 

Gillespie, Z.E., Wang, C., Vadan, F., Yu, T.Y., Ausió, J., Kusalik, A., Eskiw, C.H. (2019) Metformin induces the AP-1 transcription factor network in normal dermal fibroblasts. Scientific Reports: 9(5369): 1-17. DOI: 10.1038/s41598-019-41839-1
 

Wang, C., Eskiw, C.H. (2019) Cytoprotective effects of Avenathramide C against oxidative and inflammatory stress in normal human dermal fibroblasts. Scientific Reports: 9(2932): 1-12. DOI: 10.1038/s41598-019-39244-9

Belak, Z.R., Harkness, T., Eskiw, C.H. (2018) A rapid, high-throughput method for determining chronological lifespan in budding yeast. Journal of Biological Methods. 5(4): 1-9. DOI: 10.14440/jbm.2018.272.
 

Tyagi, M., Cheema, M.S., Dryhurst, D., Eskiw, C.H., Ausió, J. (2018) Metformin alters H2A.Z dynamics and regulates androgen dependent prostate cancer progression. Oncotarget: 9(97): 37054–37068. DOI: 10.18632/oncotarget.26457.
 

MacKay, K., Kusalik, A., Eskiw, C.H. (2018) GrapHi-C: graph-based visualization of Hi-C datasets. BMC Research Notes. 11(418): 1-8. DOI: 10.1186/s13104-018-3507-2.
 

Belak Z.R., Ovsenek, N. and Eskiw, C.H. (2018) Conserved RNA binding activity of a Yin-Yang 1 homologue in the ova of the purple sea urchin Strongylocentrotus purpuratus. Scientific Reports. 8(1): 8061. DOI: 10.1038/s41598-018-26264-0.
 

Ghavidel, A., Baxi, K., Prusinkiewicz, M., Swan, C., Belak, Z.R., Eskiw, C.H., Carvalho, C.E., Harkness, T.A. (2018) Rapid nuclear exclusion of Hcm1 in aging Saccharomyces cerevisiae leads to vacuolar alkalization and replicative senescence. G3 (Bethesda). 8(5):1579-1592. DOI: 10.1534/g3.118.200161.

Salsman, J., Stathakis, A., Parker, E., Chung, D., Anthes, L., Koskowich, K., Lahsaee, S., Gaston, D., Kukurba, K.R., Smith, K.S., Chute, I., Léger, D., Frost, L.D., Montgomery, S.D., Lewis, S.M., Eskiw, C.H., Dellaire, G. (2017) PML nuclear bodies contribute to the basal expression of the mTOR inhibitor DDIT4. Scientific Reports: 7(1):45038. DOI: 10.1038/srep45038.
 

Gillespie, Z.E., Pickering, J., and Eskiw, C.H. (2016). Better living through chemistry: caloric restriction (CR) and CR mimetics alter genome function to promote increased health and lifespan. Frontiers in Genetics. 7(142): 1-21. DOI: 10.3389/fgene.2016.00142.

Gillespie, Z.E., MacKay, K., Sander, M., Trost, B., Dawicki, W., Wickramarathna, A., Gordon, J., Eramian, M., Kill, I.R., Bridger, J.M., Kusalik, A., Mitchell, J.A., Eskiw, C.H. (2015) Rapamycin reduces fibroblast proliferation without causing quiescence and induces STAT5A/B- mediated cytokine production. Nucleus 6(6):490-506.*

*Research selected for the cover of this issue.

Trost, B., Moir, C.A., Gillespie, Z.E., Kusalik, A., Mitchell, J.A., and Eskiw, C.H. (2015) Concordance between RNA-seq data and DNA microarray data in transcriptome analysis of proliferative and quiescent fibroblasts. Royal Society Open Science. 2(9): 150402. DOI: 10.1098/rsos.150402. 

Mitchell JA. Clay I, Umlauf D, Chen C, Moir CA, Eskiw, C.H., Schoenfelder S, Chakalova L, Nagano T, and Fraser PJ, (2012) Transcriptome characterization through comparative genome-wide analysis of nuclear RNA and RNAPII association in erythroid cells. PLoS One. 2012;7(11):e49274.
 

Eskiw CH* and Fraser, P.J. (2011) Ultra-structural study of transcription factories in mouse erythroblasts. J Cell Sci. Nov 1;124(Pt 21):3676-83. * Corresponding author
 

Mehta IS, Eskiw CH, Arican HD, Kill IR, and Bridger JM (2011) Farnesyltransferase Inhibitor Treatment restores Chromosome Territory Positions and Active Chromosome Dynamics in Hutchinson-Gilford Progeria Syndrome Cells. Genome Biol. Aug 12;12(8):R74.
 

Pink R, Eskiw C H, and Carter, D. (2010) Analysis of β-globin Chromatin Micro-environment using a Novel 3C Variant, 4Cv. PLoS One. Sep 29;5(9). pii: e13045.
 

Schoenfelder S, Sexton T, Chakalova L, Cope NF, Horton A, Andrews S, Kurukuti S, Mitchell JA, Umlauf D, Dimitrova DS, Eskiw CH, Luo Y, Wei Ruan CY, Bieker JJ, and Fraser PJ (2010) Preferential associations between co-regulated genes reveal a transcriptional interactome. Nature Genetics Jan;42(1):16-7.
 

Eskiw CH, Rapp A, Carter DR and Cook PR (2008) RNA polymerase II activity is located on the surface of protein-rich transcription factories. J Cell Sci. Jun 15;121(Pt 12):1999-2007.
 

Block GJEskiw CH, Dellaire G and Bazett-Jones DP (2006) Transcriptional regulation is affected by subnuclear targeting of reporter plasmids to PML nuclear bodies. Mol Cell Biol. 2006 Dec;26(23):8814-25.
 

Dellaire G*, Eskiw CH,* Dehghani HChing RW and Bazett-Jones DP (2006)  Mitotic accumulations of PML protein contribute to the re-establishment of PML nuclear bodies in G1.  J Cell Sci. Mar 15;119(Pt 6):1034-42. *co-first authors
 

Dellaire G, Nisman R, Eskiw CH, and Bazett-Jones DP. (2004) In situ imaging and isolation of proteins using dsDNA aptamers. Nucleic Acids Res. Nov 23;32(20):e165.
 

Eskiw CH, Dellaire G, and Bazett-Jones DP (2004)  Chromatin contacts influence the integrity of PML nuclear body structure.  J. Biol. Chem. Mar 5;279(10):9577-85v
 

Eskiw CH* Dellaire G, Mymryk J and Bazett-Jones DP (2003)  Size, position and dynamic behavior of PML nuclear bodies following stress as a paradigm for supramolecular trafficking and assembly. J. Cell Sci. 116 (Pt 21):4455-66. *Cover, this article is highlighted in the “In this Issue” portion of the journal, titled PML bodies SUMO wrestle.
 

Ficzycz A, Eskiw CH, Meyer D, Hurt M, and Ovsenek N (2001) Expression, activity and subcellular localization of the Yin Yang 1 transcription factor in Xenopus oocytes and embryos.  J. Biol. Chem. Jun 22;276(25):22819-25

Additional Book Chapters and Reviews

Eskiw CH and Mitchel JA. (2014) “Transcription Factories”  in The Functional Nucleus. Springer Science+Business Media (2016)
 

Bourne G, Moir C, Bikkul U, Ahmed M, Kill IR, Eskiw CH, Tosi S, and Bridger JM. “Interphase Chromosome Behaviour in Normal and Diseased Cells” (2013) Y.B. Yurov et al. (eds.), Human Interphase Chromosomes: Biomedical Aspects, 9. Springer Science+Business Media
 

Bridger JM, Eskiw CH, Makarov EM, Tree D, Kill IR. (2011) Progeria research day at Brunel University. Nucleus, Nov 1;2(6). 
 

Cope NF, Fraser P, Eskiw CH.*  (2010) The yin and yang of chromatin spatial organization.  Genome Biology 11:204-211  *Corresponding Author
 

Eskiw CH, and Fraser PJ. (2009) Inverted rod cells see the light.  Nature Cell Biol. Jun 6 (11):68
 

Osborne C, and Eskiw CH. (2008) Where shall we meet? A role for genome    organisation and nuclear sub-compartments in mediating interchromosomal interactions. J. Cell Biochem. Apr 2;104(5):1553-1561
 

Carter DR, Eskiw CH, and Cook PR. (2008) Transcription Factories. Biochem Soc Trans. Aug;36(Pt 4):585-9
 

Bartlett JBlagojevic JCarter D, Eskiw CH, Fromaget MJob CShamsher MTrindade IFXu M. and Cook PR.  (2006) Specialized transcription factories.  Biochem Soc Symp. (73):67-75
 

Ching RWDellaire G, Eskiw CH and Bazett-Jones DP.  (2005)  PML bodies: a meeting place for genomic loci?  J Cell Sci. Mar 1;118(Pt 5):847-54
 

Eskiw CH and Bazett-Jones DP. (2002)  The promyelocytic leukemia nuclear body: sites of activity?  Biochem. Cell Biol. 80(3):301-10. 
 

Bazett-Jones DP and Eskiw, CH.  “Chromatin structure: Lessons from imaging   techniques” in Chromatin Structure: State-of-the-Art (2003).  Elsevier Science

 
Published Datasets

Gene Expression Omnibus Datasets

  • Sept 29th, 2017 -  accession number #: GSE104458
     

  • Jan 21st, 2015 - accession number #: GSE65145
     

  • March 11th, 2015 - accession number #: GSE66780